Redox regulation by sulfane sulfur and phase zero reaction of environmental electrophiles

Abstract

Accumulated evidence indicate that sulfane sulfur, which is defined as a sulfur atom with 6 valence electrons and binds covalently to other sulfur atoms, plays an essential role in protection against oxidative/electrophilic stresses because sulfane sulfur-containing molecules such as persulfide and polysulfide can be highly nucleophilic compared to the corresponding thiol group. In the symposium, I will introduce the function of sulfane sulfur in the redox regulation during oxidative/electrophilic stresses, and discuss “phase zero-reaction” of environmental electrophiles.