Signal transduction pathways associated with protection against environmental electrophiles and its regulation by reactive sulfur species

Abstract

We are exposed to a variety of environmental electrophiles such as aromatic hydrocarbon quinones in the atmosphere, methylmercury accumulated in fish, cadmium contaminated in rice. In the workshop, I will introduce that environmental electrophiles selectively and covalently modify sensor proteins such as Keap1 and HSP90 at lower concentrations, thereby activating effector molecules such as Nrf2 and HSF1, respectively. Also, role of reactive sulfur species in the regulation of redox signal transduction pathways and toxicity during electrophilic stress will be discussed.