Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
Arsenic is a well-known hazardous metalloid that exists widely in the environment. Various genome-wide screenings revealed that the intracellular glucose metabolic pathways are involved in arsenite toxicity and its defense system. Furthermore, we demonstrated that arsenite induces cytotoxicity through repression of genes involved in the synthesis of ribose-5-phosphate in pentose phosphate pathway and activation of AMPK associated with glucose metabolism. These data suggest that arsenite increased the disturbances of glucose metabolic pathways and its regulating signaling, resulting in a promotion of cytotoxicity.
