2,3,7,8-Tetrachlorodibenzo-p-dioxin次世代毒性の予防：児の性未成熟に対するα-リポ酸の回復効果

袁 鳴; 佐野 宏江; 西田 恭子; 古賀 貴之; 武田 知起; 田中 嘉孝; 石井 祐次

doi:10.14869/toxpt.48.1.0_O-11

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : O-11

DOI https://doi.org/10.14869/toxpt.48.1.0_O-11

Conference information

Host: The Japanese Society of Toxicology

Oral

Prevention of toxicity in the next generation caused by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: recovery effect of α-lipoic acid on sexual immaturity

*Ming YUAN, Hiroe SANO, Kyoko NISHIDA, Takayuki KOGA, Tomoki TAKEDA, Yoshitake TANAKA, Yuji ISHII

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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Maternal exposure to TCDD was suggested to attenuate LH production during the perinatal stage, and the supplementation of α-lipoic acid to TCDD-exposed pregnant dams showed a recovery effect on the attenuated LH production during the gestational period. Therefore, it was expected that α-lipoic acid supplementation would have a recovery effect on the retardation of the male offspring’s sexual immaturity induced by maternal exposure to TCDD. This study suggests that maternal supplementation with α-lipoic acid has a restoring effect on the decreased SDN-POA volume, which is an indicator of sexual differentiation in male offspring.

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