Contribution of DHA metabolites to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson’s disease

Abstract

DHA has been shown to have neuroprotective effects in Parkinson’s disease, but the underlying mechanism has not been fully elucidated. DHA is metabolized to DHA epoxides by P450s and further hydroxylated to the corresponding diols (DHDPs) by sEH. In this study DHA intake in rats improved the motor dysfunction induced by rotenone. However, these effects were eliminated by cosupplementation with the sEH inhibitor. DHA intake increased the amount of 19,20-DHDP in the rat brain. These results suggest that DHA metabolites have an important role in improving rotenone-induced Parkinson’s disease.