Host: The Japanese Society of Toxicology
Thoracolumbar supernumerary ribs (TSR, 14th rib) are skeletal findings observed in fetuses in teratogenicity studies. We have reported the mechanism of 5-FC induced TSR (Kumamoto et al., FTS, 2020; Kuwagata et al., CGA, 2018), but the spontaneous development remains unclear. In this study, we conducted to elucidate by sequence analysis rat strains (Wistar / SD). Although no significant differences were observed in most sites of homeobox genes, a significant difference was shown in a certain region, which overlaps with a miRNA that negatively regulate the expression of multiple Hox genes and control posteriorization of axial skeleton.
