Binding properties of human C8 gamma against organo-metal compounds

Abstract

We previously reported that mouse C8γ binds to tri-substituted organotin compounds such as triphenyltin (TPT) and may play an important role in the toxicity of TPT. However, in such carrier molecules, their binding properties are often different among species because of species differences in amino acid sequences. We here evaluated binding affinity of chemical substances to human C8γ protein. We found that it also has specific binding to TPT and group 14 compounds with tri-phenyl substituent. These results suggest that C8γ may play an important role in the toxicity of these compounds in human, too.