An attempt to detect psychiatric adverse events by evaluation of social behavior of pair-housing dogs living in EURO Guide-compliant cages

Abstract

Because detecting psychiatric adverse effects are difficult in conventional nonclinical toxicity studies, we attempted to detect them by evaluating social behavior of pair-housing dog living in EURO Guide-compliant cages. Diazepam was intravenously administered to beagle dogs and they were observed with a focus on their social behavior, either directly or by video. As a result, diazepam induced increased activity and sniff with following the other dog in behavioral patterns, which we considered suggesting psychological adverse effects.