Influence of subacute oral exposure to inorganic arsenic on pathology of atopic dermatitis and allergic asthma

Abstract

We investigated the intervention of inorganic arsenic (AS, 10 ppm) exposure with allergic diseases. Atopic dermatitis (AD) and asthma models were developed by repetitive administration of 2.4-Toluenediisocyanate and mite allergen, respectively. In the AD model, trans epidermal water loss and AD symptoms were significantly aggravated by AS exposure. AS exposure also significantly increased the amount of Th2 cytokines, IL-33, TSLP, IgE positive B cells and total serum IgE in both models. Our findings imply that AS exposure exacerbated the pathology of allergy in mouse models.