Host: The Japanese Society of Toxicology
Excess reactive oxygen species (ROS)-induced vascular smooth muscle cell (VSMC) hypermigration contributes to the development of arteriosclerosis. Here we show that intracellular sulfane sulfur donors inhibited the migration of VSMCs in response to PDGF. Specifically, PDGF increased the levels of cellular ROS, which were decreased by sulfane sulfur donors. Further, such molecules inhibited PDGF-induced activation of Akt and formation of focal adhesions. These findings suggest that sulfane sulfurs regulate ROS-dependent PDGF signaling, which may contribute to PDGF-induced migration of VSMCs.
