Host: The Japanese Society of Toxicology
Methylmercury (MeHg) induces neuronal degeneration in the brain, but mechanisms are unclear, which underlie cell selectivity and developmental dependency. It is hard to analyze them at an appropriate stage by monitoring Hg of the dissected brain. To address this issue, we developed sensor vectors for MeHg toxicity.
The study of selenoprotein showed that MeHg inhibits the insertion of selenocysteine (Sec) during translation. By utilizing this new toxic model, vectors were designed to show MeHg-dependent signals and evaluated for sensors. We will present and discuss these results.
