Two distinct molecular mechanisms underlying the pro-apoptotic function of trans-fatty acids in response to various types of DNA lesions

Abstract

Compelling epidemiological evidence has shown that trans-fatty acids (TFAs) consumption are associated with various diseases including atherosclerosis. However, the underlying mechanisms are largely unknown. Here, we show that elaidic acid, the most abundant TFA in foods, promotes apoptosis induced by cisplatin (a DNA crosslinking agent) in a p53-dependent manner, while that induced by doxorubicin (a DNA double-strand break-inducing agent) in a p53-independent manner. In this meeting, we discuss the difference of the underlying mechanisms between two types of apoptosis facilitated by TFAs.