Cannabidiolic acid mediated-down-regulation of COX-2 expression through the abrogation of PPARβ/δ signaling

Abstract

We previously demonstrated that cannabidiolic acid, a major component of the fiber-type cannabis plant, down-regulates COX-2 expression and inhibits cell migration in human breast cancer MDA-MB-231 cells (Toxicol. Lett., 2012; J. Toxicol. Sci., 2014; J. Nat. Med., 2017; Nat. Prod. Commun., 2017; J. Toxicol. Sci., 2020). However, the details of down-regulation mechanisms of COX-2 expression by CBDA are still unknown. Here, we show that CBDA can down-regulate COX-2 expression through the abrogation of PPARβ/δ signaling.