Host: The Japanese Society of Toxicology
Drug-induced fatal liver injury is a serious concern, but its mechanism is unclear. We hypothesized that inhibition by drugs of inflammatory reaction and fibrosis essential for liver regeneration could finally induce fatal outcome. Then we focused on hepatic stellate cells, which is closely associated with fibrosis. Present study investigated the effects of benzbromarone (BBR), that induced fatal liver injury in clinical, on hepatic stellate cell line LX-2.
As a result, BBR suppressed inflammatory response and fibrosis, which may be due to a decrease in mitochondrial membrane potential.
