A role of PGRMC1, membrane-bound heme protein, on induction of ferroptosis

Abstract

We attempted to elucidate a role of PGRMC1, membrane-bound heme protein, on induction of ferroptosis. In this study, we showed that overexpression of PGRMC1 increased the sensitivity to ferroptosis promoters, and that ferroptosis promoters-treatment increased lipid peroxide, decreased intracellular free heme concentration, and increased intracellular free iron in PGRMC1 stable expression cell lines. These results suggest that overexpression of PGRMC1 might suppress the ability to resist ferroptosis promoters in lung cancer cells.