Host: The Japanese Society of Toxicology
Various urinary biomarkers (BMs) are used to detect drug nephrotoxicity invasively. Urine for BMs are usually sampled overnight, stored at cold. To investigate 4-hour fresh urine utility for nephrotoxicity BM, GM (Gentamicin) or CDDP (Cisplatin) was administered to rats, and urine/blood BMs and renal histopathology were examined.
The increases in urinary BMs (Kim-1, NGAL, etc.) were noted in fresh urine (ice-cold storage), and had correlation with renal histopathologic changes of proximal tubule. In conclusion, the flesh urine would be applicable to detect nephrotoxicity through urinary BMs.
