Host: The Japanese Society of Toxicology
Toxicity study of ophthalmic drugs has unique characteristics of its study design and packages. The present survey was carried out in order to review toxicity of 5 intravitreal drugs those have been approved in Japan, and to compare clinical adverse effects with nonclinical toxicity. This survey is valuable for considering the toxicity study design, and suggested that there is a limitation to predict clinical adverse effects from nonclinical study results especially in retinal vascular lesions which might be attributed immunoreaction.
