LLNA:BrdU-ELISAによる実用的GHS細区分基準の設定

谷川 久子; 小林 俊夫; 前田 洋祐; 近藤 悠; 武吉 正博

doi:10.14869/toxpt.48.1.0_P-187E

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-187E

DOI https://doi.org/10.14869/toxpt.48.1.0_P-187E

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Host: The Japanese Society of Toxicology

e-Poster

Setting of practical GHS-subcategorization criterion for LLNA: BrdU-ELISA

*Hisako TANIGAWA, Toshio KOBAYASHI, Yosuke MAEDA, Haruka KONDO, Masahiro TAKEYOSHI

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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

The LLNA: BrdU-ELISA can be used to classify GHS category 1 chemicals, but a sub-categorization criterion has not been provided. Here, we reanalyzed 32 sensitizers listed in the ICCVAM peer-review data set and proposed an optimal sub-categorization criterion for LLNA: BrdU-ELISA as 6% when using EC1.6. Additionally, we confirmed its applicability to CBA/J mice with 15 sensitizers listed in the LLNA performance standard and confirmed correct assignment of their sub-categories. Consequently, the newly proposed criterion appears to be applicable for practical use for GHS sub-categorization.

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