Host: The Japanese Society of Toxicology
Transcriptome data of cultured cells treated with small compounds are profile data and their analysis enables us to evaluate toxicity of compounds. The effects of compounds are complex, and it is difficult to detect relatively weak secondary effects by general methods that lump all the characteristics of compounds together. To address this issue, we have developed a method to separate and understand the effects of compounds. In this study, we applied this method to two compounds of natural origin with similar structures, and evaluated their ability to detect unreported effects and to discriminate between compounds with similar structures.
