Fe3O4-PEG-PLGAの経気道曝露による野生型およびNrf2欠損マウスの肺への影響の評価

佐藤 春恵; 宗 才; Stéphanie DEVINEAU; Claire MCCORD; 市原 佐保子; Oliver BROOKES; Frederick Adams EKUBAN; 伊東 健; 山本 雅之; Sonja BOLAND; Armelle BAEZA-SQUIBAN; 市原 学

doi:10.14869/toxpt.48.1.0_P-32S

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-32S

DOI https://doi.org/10.14869/toxpt.48.1.0_P-32S

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Pulmonary effects of Fe3O4-PEG-PLGA nanoparticles in wild type and Nrf2 knockout mice following pharyngeal aspiration

*Harue SATO, Cai ZONG, Stéphanie DEVINEAU, Claire MCCORD, Sahoko ICHIHARA, Oliver BROOKES, Frederick Adams EKUBAN, Ken ITOH, Masayuki YAMAMOTO, Sonja BOLAND, Armelle BAEZA-SQUIBAN, Gaku ICHIHARA

Author information

*Harue SATO
Faculty of Pharmaceutical Sciences, Tokyo University of Science
Cai ZONG
Faculty of Pharmaceutical Sciences, Tokyo University of Science
Stéphanie DEVINEAU
Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France
Claire MCCORD
Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France
Sahoko ICHIHARA
School of Medicine, Jichi Medical University
Oliver BROOKES
Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France
Frederick Adams EKUBAN
Faculty of Pharmaceutical Sciences, Tokyo University of Science
Ken ITOH
Graduate School of Medicine, Hirosaki University
Masayuki YAMAMOTO
Graduate School of Medicine, Tohoku University
Sonja BOLAND
Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France
Armelle BAEZA-SQUIBAN
Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France
Gaku ICHIHARA
Faculty of Pharmaceutical Sciences, Tokyo University of Science

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Abstract

This study investigated pulmonary effects of exposure to Fe₃O₄-PEG-PLGA nanoparticles (NPs) and role of Nrf2. Exposure to Fe₃O₄-PEG-PLGA NPs increased total cells and macrophages in wild-type (WT) mice, lymphocytes, neutrophils and eosinophils in Nrf2 KO mice, and basophils in both genotypes. Exposure to Fe₃O₄-PEG-PLGA NPs increased pulmonary expression of TNF-alpha, KC and MIP-2 only in Nrf2 KO mice, and SOD-1, GcLc, GcLm, MMP-2, and TGF-beta only in WT mice. The results suggest that Nrf2 plays a role in regulation on leucocyte migration and inflammatory response induced by Fe₃O₄-PEG-PLGA NPs.

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