Effects of particle matter 2.5 (PM2.5) exposure on the prognosis of ischemic stroke in mice

Abstract

We aimed to examine the effects of PM2.5 exposure on the prognosis of ischemic stroke in mice. Mice were intranasally administered PM2.5 for 7 days and then subjected to focal cerebral ischemia. The prognosis was noticeably aggravated by PM2.5 exposure compared with vehicle-treated mice. Polycyclic aromatic hydrocarbons (PAHs) induced inflammatory reaction in macrophages and PM2.5 core, by which PAHs were removed, did not affect the prognosis. Together, we have demonstrated for the first time that neuroinflammation induced by PM2.5 exposure can aggravate the outcome of ischemic stroke.