Host: The Japanese Society of Toxicology
Seizure is a severe adverse effect in neurotoxicity. In particular, seizure has a huge impact on drug development. Therefore, detection of seizure potential risk is the most important subjects in non-clinical studies. Electroencephalography (EEG) is a useful tool to monitor neuronal activity, and characteristic EEG waveform of seizure has been reported in both animals and humans, but there are few reports of EEG waveform for evaluation of seizure potential. In this study, we established a novel analytical method for detection of seizure potential from different perspective using EEG waveform in pre-seizure state.
