非アルコール性脂肪肝 (NAFL) モデル動物を用いたニコチンアミドによる脂肪肝改善メカニズムに関する研究

横内 千恵; 西村 悠花里; 後藤 浩彦; 佐藤 亮; 日堂 佑哉; 竹内 健二; 石井 祐次

doi:10.14869/toxpt.48.1.0_P-44E

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-44E

DOI https://doi.org/10.14869/toxpt.48.1.0_P-44E

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Study on the mechanism of fatty liver improvement by nicotinamide in non-alcoholic fatty liver (NAFL) model animals

*Chie YOKOUCHI, Yukari NISHIMURA, Hirohiko GOTO, Makoto SATO, Yuya HIDOH, Kenji TAKEUCHI, Yuji ISHII

Author information

*Chie YOKOUCHI
Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University
Yukari NISHIMURA
Department of Drug Safety, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
Hirohiko GOTO
Department of Drug Safety, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
Makoto SATO
Department of Drug Safety, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
Yuya HIDOH
Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
Kenji TAKEUCHI
Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
Yuji ISHII
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

Our recent studies have shown that the co-administration of nicotinamide (NAM), a precursor of methylnicotinamide (MNA), with S-adenosylmethionine (SAM) and hydralazine (HYD) significantly improves fatty liver in a rat model of NAFL. In this study, we conducted the in vitro metabolism studies using hepatic homogenate prepared from NAFL rats to explore some of the mechanisms of fatty liver improvement by NAM. Consequently, it was suggested that the combined administration of SAM and HYD efficiently increases the hepatic MNA exposure and led to the improvement of fatty liver in rats.

Corresponding author

Register with J-STAGE for free!