Evaluation of drug metabolism and drug-induced toxicity using polydimethylsiloxane-based liver-on-a-chip

Abstract

Most liver-on-a-chips are fabricated from PDMS which is a material that easily absorbs drugs. However, it is unclear that PDMS-based liver-on-a-chip could be used for drug evaluation. Here, we found that the absorption ratio of drugs into the PDMS-based device correlates with S+logD value of drugs. Additionally, we confirmed that drug responsiveness assay could be performed by using drugs with low S+logD value in the PDMS-based liver-on-a-chip. These results suggested that PDMS-based liver-on-a-chip could be useful for pharmaceutical research.