Host: The Japanese Society of Toxicology
Our previous study demonstrated that Cd inhibited the activities of RAR and PPARD transcription factors. In this study, the pretreatment of HK-2 cells with retinoic acid (RA) and its precursor, retinol, conferred resistance to Cd. In addition, PPARD knockdown showed resistance to Cd in HK-2 cells but not RARG (one of RAR subtype) knockdown. On the other hand, treatment of PPARD knockdown cells with RA strengthened resistance to Cd compared with each alone group. These results suggested that RA and PPARD knockdown play protective rolls against Cd toxicity.
