Annual Meeting of the Japanese Society of Toxicology
The 48th Annual Meeting of the Japanese Society of Toxicology
Session ID : P-57
Conference information

Host: The Japanese Society of Toxicology

e-Poster
CD44 expression in transition from cisplatin-induced acute kidney injury to chronic kidney disease
*Kohei MATSUSHITA, Takeshi TOYODA, Hirotoshi AKANE, Tomomi MORIKAWA, Kumiko OGAWA
Author information
CONFERENCE PROCEEDINGS FREE ACCESS

Details
Download PDF (124K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

To clarify the role of CD44 in acute kidney injury to chronic kidney disease transition, 6-week-old male SD rats were treated with 6 mg/kg of cisplatin and necropsied after 1 to 28 days. CD44 was expressed in dilated tubules after day 5 and dilated/atrophic tubules in fibrotic lesions after day 14. At day 28, pathway analysis indicated CD44 as inducer of fibrosis related genes, such as Fn1. Fn1 mRNA and protein were expressed in cytoplasm of dilated/atrophic tubules and stroma, respectively. These results indicated CD44 as trigger of extracellular matrix secretion in dilated/atrophic tubules.

Content from these authors
© 2021 The Japanese Society of Toxicology
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

Annual Meeting of the Japanese Society of Toxicology

Share this page
feedback
 Top