Utility of computed tomography (CT) in bleomycin-induced lung fibrosis mice model: Non-invasive quantitative evaluation of lung injury, 2nd report

Abstract

In computerized tomography (CT) tests that are commonly used in clinical medicine, CT images are usually evaluated by a radiologist. However, manual interpretation can lead to differences between evaluators and lacks objectivity. In this investigation, a method for quantifying CT images that enables objective and simple evaluation of lung injury was established. A bleomycin-induced mice lung injury model was evaluated using micro-CT tests. This report presents the utility of the semi-automatically calculated CT value as a new biomarker of lung injury in non-clinical studies.