Development of Cardiotoxicity Assessment Method for Combined Administration of Trastuzumab (TRZ) and Doxorubicin (DOX) in Mice - Myocardial Strain (GLS) by Speckle-tracking Echocardiography -

Abstract

Cardiotoxicities associated with combination cancer therapy have become a hot topic of concerns. In this study, we developed a new assessment method to predict the onset of such cardiotoxicity. Male mice received TRZ and DOX at 20 or 3 mg/kg once a week for 10 weeks by single or combined administration. ECG, echocardiography, blood and histopathological examinations and PCR assay of the heart were performed. These results indicate that this method is highly valuable for assessing cardiotoxicity of molecularly targeted drugs, which may help figure out issues in the cardio-oncology.