Cases of suspected NSAIDs intolerance of microminipigs caused by acetaminophen administration

Abstract

28-day repeated oral toxicity study of acetaminophen (APAP) in microminipigs (MMP, Fuji Micra Inc.) was performed. MMPs (male, n=3) were administered APAP at 0, 80, 200 and 600 mg/kg body weight/day. Swelling of head, redness, pruritus were observed in all MMPs at 600 mg/kg and they died on day 3. Histologically, subcutaneous edema with granulocyte infiltration and fibrin deposition that suggest increased vascular permeability were observed. These findings are the features of NSAIDs intolerance, and allergies to APAP were unlikely, the involvement of the disease was suspected.