Annual Meeting of the Japanese Society of Toxicology
The 48th Annual Meeting of the Japanese Society of Toxicology
Session ID : P-87E
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e-Poster
Maternal exposure effect of glyphosate and glyphosate-based herbicide on hippocampal neurogenesis in rats
*Ryota OJIROHiromu OKANOKazumi TAKASHIMAYasunori TAKAHASHIQian TANGSatomi KIKUCHIToshinori YOSHIDAMakoto SHIBUTANI
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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Maternal exposure effect of glyphosate (GlyP) and glyphosate-based herbicide (GBH) on hippocampal neurogenesis was examined in rats. Pregnant rats were treated with 0, 15,000, or 30,000 ppm GlyP via diet and 1% GBH via drinking water from gestational day 6 to postnatal day (PND) 21, and offspring were examined on PND 21 and PND 77. As a result, GlyP and GBH decreased proliferation of neurogenic niche and increased synaptic plasticity of granule cells transiently on PND 21. However, GBH further induced oxidative stress in the dentate gyrus on PND 77.

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