Application of adult toxicity prediction system using human ESCs

Abstract

We reported a high accuracy toxicity prediction system using human ES cells in 2016. As next challenges, we report the results of an attempt to apply it to the adult toxins such as nephrotoxins, neurotoxins, and hepatotoxins. Toxicity prediction was performed using gene expression data of about 20 chemicals in human ES cells, and it was found that, for example, hepatotoxins can be predicted with a high accuracy of 90.5%. This prediction system, which uses human ES cells as a reaction device for chemicals, can apply mixtures that have been difficult to predict, and can be used as an unknown primary toxicity screening. As the number of chemicals increases in the future, it is expected that the effects of machine learning will be progressed and the prediction system will become more robust.