Host: The Japanese Society of Toxicology
We have developed a system that realizes toxicity prediction with a high-precision prediction rate of 90-95% or more by exposing undifferentiated human ES cells to toxic substances regardless of development or adulthood. By expanding the range of applicable target organs and creating a database of nerve, liver, kidney, heart, and carcinogenic (arbitrary organ) toxicity, hazard prediction became possible. Since this system uses undifferentiated cells, it is an epoch-making system that can theoretically predict the toxicity of multiple target organs with one test. For detailed AOP analysis, the conventional system using differentiated cells is effective, when the target is unknown, it is necessary to use as many differentiated cells as the number of organs, leaving problems in standardization and long-term development. This system can be facilitated as a primary screening to find a target, and is expected to be very effective because it can be executed at low cost and in a short time. Therefore, the development of a database is important, and we selected and listed 1,488 chemical substances to register at five levels according to the importance.
