Safety assessment for CMR

Abstract

For human health of pesticides, carcinogenicity, mutagenicity, and reproductive toxicity (CMR) are important toxicity endpoints. When certain tumors may increase, mechanistic studies for Adverse Outcome Pathway (AOP) using biochemical, molecular biological, and pathological methods can provide useful information for human-relevance. If in vitro genotoxicity is equivocal or positive, in vivo genotoxicity results come to be definitive considering evidence of exposure to the target tissue. Regarding to effects on reproductive performance or next generation, hormone measurements and searches for early key events can be indicators for weight of evidence.