Host: The Japanese Society of Toxicology
There are large species differences in sensitivity to exogenous chemicals (xenobiotics). One of the causes of these species differences is species differences in the metabolism of chemicals and their binding to various receptors. In this symposium, we will invite researchers who have been studying species differences in response to xenobiotics and share the latest research results.
In this presentation, I will first outline the species differences in metabolism of cytochrome P450 (CYP) and other phase I and mammalian glucuronosyl transferase (UGT) phase II xenobiotics, including the latest data. We have reported the pseudogeneity of CYP and UGT in predators of animal species. In this talk, as an introduction to the symposium, I will outline which enzymes are pseudogenized in which species and discuss the characteristics of xenobiotics metabolism in each animal species.
