Host: The Japanese Society of Toxicology
Knowing the metabolic capacity of xenobiotics in birds is important for poultry management and ecosystem conservation. In previous studies, we have analyzed the sequences and expression levels of avian cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs), and hepatic metabolic activities. As a result, it was indicated that the expression pattern of CYP1-3 genes in the liver differed among birds. In addition, the counts of UGT1 genes tended to be smaller and the glucuronide conjugation activity also tended to be lower in carnivorous birds. In this presentation, I will introduce the species difference and evolution of xenobiotic metabolism in birds.
