Host: The Japanese Society of Toxicology
Cynomolgus macaques, important non-human primates used in drug metabolism and toxicity studies, show drug metabolism patterns generally similar to humans. However, some differences are occasionally noted due to species differences in drug-metabolizing enzymes such as cytochrome P450 (CYP) including CYP2C9, CYP2C19, and monkey-specific CYP2C76. Similarly, we also found some differences in UDP-glucuronosyltransferase (UGT), including UGT1A6 and UGT1A9, possibly accounting for species differences of UGT metabolism recently noted between monkeys and humans in drug metabolism studies. The results of other drug-metabolizing enzymes will be also presented.
