Host: The Japanese Society of Toxicology
Traditionally, the toxicological target of inhaled formalin (FA) gas was the nasal cavity, and the authorities said that FA will be trapped there and never reaches the lung tissue. However, when we exposed mice to FA gas at a low “sick building syndrome” level of concentration, clear transcriptomic effect of lung and liver were observed. This finding strongly suggested inhalation toxicology should follow what we learn from anaesthesiology, i.e. the end-tidal anaesthetic concentrations reflects the blood concentration in equilibrium.
We will report the lung and liver transcriptomic data on some volatile chemicals and discuss on the mechanistic prediction of pulmonary and systemic toxicity. (Supported by Health and Labour Sciences Research Grant).
