Host: The Japanese Society of Toxicology
Normal animals have been commonly used in toxicity studies, but recently the development of animal models for human diseases has been remarkably progressed, and model animals are used for toxicity studies, especially in new modalities. Since there could be differences in responses to test articles between normal and pathological model animals, findings in model animals need to be carefully extrapolated to human. In this presentation, I will introduce case studies of translational research for toxicity findings in disease model animals, which were observed in pharmacological studies.