Drug-induced seizure risk assessments based on in vitro, ex vivo, in vivo neural network activities

Abstract

In this symposium, we will introduce the changes in electrical activities for seizure-positive compounds in cultured cells, brain organoids, brain slices, and in vivo brain, and the AI analysis methods for predicting seizure risk from waveforms. In addition, we will also introduce a method for predicting the mechanism of action from waveforms and a method for predicting the aura state of drug-induced seizures. I would like to discuss the interpretation and consistency of data obtained in vitro, ex vivo, in vivo.