Host: The Japanese Society of Toxicology
Cytotoxic anticancer drugs frequently causes various adverse effects, while some of them, such as peripheral neuropathy or oral mucositis, are still uncontrolled. We found that taxanes induce dedifferentiation of Schwann cells, resulting chemotherapy-induced peripheral neuropathy. By screening drugs that has the ability to induce Schwann cell differentiation, we found that cilostazol, a PDE inhibitor, inhibit taxane-induced Schwann cell dedifferentiation and reduced painful responses in animals. Furthermore, I will introduce the effect of Hangeshashinto oral ointment, a Chinese herbal medicine, on chemotherapy-induced oral mucositis. We are now preparing to conduct clinical trials.
