Host: The Japanese Society of Toxicology
Name : The 49th Annual Meeting of the Japanese Society of Toxicology
Date : June 30, 2022 - July 02, 2022
Organ-on-a-Chip (OOC) technology is increasingly able to provide a comprehensive view of physiological phenomena in healthy and diseased states. In particular, this technology is being applied primarily for preclinical testing as an alternative to animal testing. Furthermore, in order to efficiently create drugs, it is important to comprehensively evaluate drug efficacy as well as toxicity and drug metabolism from the early stages of drug discovery. In the early stages of drug discovery, high-throughput screening (HTS) is necessary to evaluate a wide variety of compounds at once using a small amount of compounds. However, the complexity and precision of OOC makes automated culture difficult and has not yet been put to practical use. In addition, the complex three-dimensional structure of cultured tissues poses a challenge to the development of assay technologies that can obtain sufficient data to quantify and interpret physiological phenomena with high efficiency.
Here, we introduce a case study of screening related to kidney and blood vessels using MIMETAS Organ-on-a-chip, which is designed to be applied to automated culture and analysis devices, and an attempt to quantify the behavior of cells in the immune system, and discuss how OOC can be used for HTS in the future. Challenges and prospects for its use will be presented.
