Host: The Japanese Society of Toxicology
Name : The 49th Annual Meeting of the Japanese Society of Toxicology
Date : June 30, 2022 - July 02, 2022
Circadian rhythms are endogenous 24 h oscillations in biological and behavioral patterns common to all living organisms. The circadian clock drives oscillations in a diverse set of biological processes, including locomotion, sleep, blood pressure, blood hormone levels, and body temperature. Additionally, it is also known that circadian rhythms affect directly affect disease frequency. For example, there are higher occurrences of asthma at midnight and myocardial ischemia in the morning. Moreover, it is well reported that circadian time-dependent differences change the pharmacokinetics of medications, such as anticancer drugs and antibiotics. These research field is named as “chronopharmacology” and are well studied. In contrast, circadian rhythms related toxicology is limited compared to chronopharmacology.
We have interested in the “chronotoxicology” as which we advocated the relationship between the administration timing and the toxic severity of chemicals.
Interestingly, our previous studies clearly indicated that mice showed remarkable daily fluctuations in the severity of the toxic response to Cd; all mice died when injected in the morning (10:00 am), but all mice survived when injected at night (2:00 am) [Miura et al, J Toxicol Sci, 2012, 2013, 2017]. We also indicated that other metals and chemicals showed specific toxic fluctuation [Yoshioka et al, J Toxicol Sci, 2017, 2018/ Biol Pharm Bull, 2020, 2021].
In this symposium, we would like to introduce latest research related to metal and chemical-induced diurnal toxic injury.
