Host: The Japanese Society of Toxicology
Name : The 49th Annual Meeting of the Japanese Society of Toxicology
Date : June 30, 2022 - July 02, 2022
The sensory organs playing a very important role in obtaining information, the eyes are an assembly of complexly differentiated specialized organs that achieve visual capability by maintaining integrated physiological homeostasis. While many mechanisms maintaining homeostasis are shared across laboratory animal species, many species differences between humans and laboratory animals are known. In evaluation of ocular toxicity, in addition to the above, extensive knowledge of eye anatomy, physiology, biochemistry, occurrence, and pathology are necessary. Further, in non-clinical ophthalmology, many incidental lesions are noted. For example, while corneal damage and cataracts are sometimes induced by drug dosing, opacity in the cornea and lens are lesions that spontaneously occur with age in albino rats commonly used in non-clinical toxicity studies. In toxicity evaluation, there are cases where differentiating between the effects of dosing and these types of incidental lesions is difficult, the knowledge related to the eye in laboratory animals are indispensable in non-clinical toxicity studies for eye pharmaceutical development.
In this presentation I’ll discuss fundamental characteristics of eye anatomy and physiology in several species, as well as incidental lesions and lesions induced by external physical trauma.
