Host: The Japanese Society of Toxicology
Name : The 50th Annual Meeting of the Japanese Society of Toxicology
Date : June 19, 2023 - June 21, 2023
Human body consists of the major elements (ca. 99.3%) such as oxygen (65%), carbon (18%), hydrogen (10%), nitrogen (3.0%), calcium, phosphorus, sulfur, potassium, sodium, chlorine and magnesium, and trace elements which exist in an amount of less than 0.01%. However, the trace elements have crucial and various roles in physiology and toxicology. Since trace elements are, as the name implies, "trace," their presence in living organisms has been studied for the major purpose of quantifing their total contents in the body. In addition, elemental speciation and imaging are also key techniques to understand the physiological and toxicological roles of trace elements. I have been developing four advanced and hyphenated techniques based on inductively coupled plasma mass spectrometry to reveal the roles. The following techniques were utilized for my research in metal/metalloid toxicology, 1) Speciation; ICP-MS was used as a detector of HPLC (LC-ICP-MS), 2) Laser ablation (LA); LA was used for a sample introduction of ICP-MS (LA-ICP-MS), 3) Single particle/single cell ICP-MS; ICP-MS having a high time-resolve mode was applied to an elemental analysis in a single particle/single cell (sp/scICP-MS), 4) Asymmetry flow field flow fractionation (AF4); AF4 is hyphenated with ICP-MS to analyze nanomaterials (AF4-ICP-MS).
