Host: The Japanese Society of Toxicology
Name : The 51st Annual Meeting of the Japanese Society of Toxicology
Date : July 03, 2024 - July 05, 2024
Dogs and pigs, together with cynomolgus macaques, are important animal species in drug metabolism and toxicity studies. However, some differences in drug metabolism patterns are occasionally noted due to species differences in cytochromes P450 (P450, CYP), important drug-metabolizing enzymes. To understand the species differences, we have identified and characterized P450s in a systematical manner in these animal species. In dogs, pigs, and cynomolgus macaques, a 1-to-1 relationship to human P450s were found for most P450s (including CYP1A, CYP2D, and CYP2E), but not for some P450s, including CYP2Cs partly due to species-specific P450s such as cynomolgus CYP2C76. Moreover, some P450s show substrate specificity and hepatic expression profile different from humans in dogs, pigs, and cynomolgus macaques. These results partly explain species differences in drug metabolism. Finally, we also have identified and characterized P450s in tree shrews, the species once categorized as primates and currently used mainly for virus research, to assess their usefulness in drug metabolism studies, and will present some of the results. This presentation will be mainly on CYP1A, CYP2A, CYP2B, CYP2D, and CYP2E.
