Host: The Japanese Society of Toxicology
Name : The 51st Annual Meeting of the Japanese Society of Toxicology
Date : July 03, 2024 - July 05, 2024
Various in vitro assay systems have been used in the predictive toxicology field and are essential to mitigate safety concerns in drug discovery. (Loiodice et al, 2019). However, conventional many in vitro assay systems are conventionally applied single cells cultured on a flat surface for evaluation, making it difficult to evaluate the complex toxicities contributed by multiple cell types. Recently, microphysiological systems (MPS), which are advanced in vitro models such as Organ-on-a-Chip and Organoids, have been developed, and it was expected that they would make it possible to evaluate complex toxicity, beyond conventional in vitro assay systems. In our company, MPS is increasingly being used in safety evaluation for various areas such as hepatotoxicity and neurotoxicity. In this presentation, we will introduce in-house application examples of MPS such as Organ-on-a-Chip and Organoid in the early safety evaluation, and share the benefit with the example of platelet aggregation assay. MPS was expected to be a game changer in the early safety evaluation within five years as of 2020, whereas the use of MPS is still limited, and it is difficult to say that it has achieved the expected results. In this presentation, we focus on the gap between the ideal and reality required for advanced in vitro models, and discuss the factors limiting the use of MPS in the early safety evaluation.
