Host: The Japanese Society of Toxicology
Name : The 51st Annual Meeting of the Japanese Society of Toxicology
Date : July 03, 2024 - July 05, 2024
Unique bioactive compounds produced by microorganisms always have specific target molecules in the cell. Their identification has been useful information for drug discovery. We have so far identified many gene expression regulators as the targets, including histone deacetylases that control epigenetics, all of which are important targets for new anticancer drugs. However, the identification of target molecules of active compounds requires experience, knowledge, and insight, and systematic analysis has been difficult. We have been trying to establish a bias-free method for the identification of compound targets using chemical genomics with gene disruption and gene overexpression in yeast and phenotypic analysis by systematic gene knockdown in animal cells. In this talk, we will present the history of chemical genetics and the forefront of chemical genomics.
