Host: The Japanese Society of Toxicology
Name : The 51st Annual Meeting of the Japanese Society of Toxicology
Date : July 03, 2024 - July 05, 2024
We do not fully understand the effects and mechanisms of drugs clinically used in humans. This is because it is impossible to comprehensively measure the affinity for various receptors during drug development, and efficacy and safety studies in humans are also insufficient. In fact, it is not uncommon for a drug to find unknown harmful or beneficial effects on humans. In this talk, I will introduce the following results that aim to identify unexpected beneficial effects of drugs through the analysis of actual clinical real-world data, especially cases of adverse events, and to reevaluate drugs and discover novel drug targets.
(1) Usefulness and the mechanism of a thrombin inhibitor dabigatran for the interstitial lung disease caused by the antiarrhythmic drug amiodarone
(2) Usefulness and the mechanism of lisinopril for bullous pemphigus induced by the antidiabetic DPP4 inhibitors
(3) Usefulness and the mechanism of dexamethasone for tendinopathy caused by fluoroquinolone antibiotics
(4) Neural mechanism of proton pump inhibitors suppressing the risk of obsessive-compulsive disorder increased by dopamine D2 receptor stimulants
