Host: The Japanese Society of Toxicology
Name : The 51st Annual Meeting of the Japanese Society of Toxicology
Date : July 03, 2024 - July 05, 2024
The history of non-clinical safety evaluation for pharmaceuticals dates back to the early 20th century when animal experiments were first conducted to provide information on the toxicity of chemical substances and drugs.
In the 1950s, regulatory authorities and international organizations engaged in discussions regarding the essential toxicity evaluation parameters necessary for drug development and ensuring safety for humans. These discussions led to the creation of various toxicity testing guidelines.
While standardized toxicity evaluation methods have been established, the need for continuous improvement in toxicity detection, including refinement of evaluation criteria, has arisen due to adverse events observed in humans. Additionally, the diversification of drug modalities has highlighted the limitations of existing evaluation approaches, prompting the development of novel technologies from a more scientific perspective.
Furthermore, efforts have been made to develop evaluation methods and technological innovations aimed at reducing the number of animals from the perspective of animal welfare. In this introduction, we aim to provide an overview of the objectives of this workshop and explore the historical evolution of toxicity assessment methods and technologies.
