Drug reprofiling and repurposing: a state-of-the-art public-private collaboration model

Abstract

Drug repurposing is being actively pursued as a cost- and time-efficient drug discovery and development strategy. We proposed a new public-private partnership model for drug repurposing that involves academic institutions, government, investors, pharmaceutical and biotech companies. The model initially identifies promising hypothesis based on information of pharma assets on shelves, and proves the hypothesis in early clinical settings through academic and industry collaborations. We are currently developing multiple clinical assets including ART-001, a novel PI3Kα inhibitor for complex vascular malformations, based on this strategy to prove the model as a highly productive drug discovery and drug development framework.